A new avenue to the synthesis of highly substituted pyrroles: synthesis from N-propargylamines

Abstract

Pyrroles have attracted much attention due to their potential biological activities. Developing more efficient methods for the generation of pyrrole cores with unusual substitution patterns e.g. 2,4-disubstituted pyrroles is particularly interesting. This review gives an overview of new developments in the synthesis of highly substituted pyrroles from N-propargylamines in recent years.