A metal-free tandem ring-opening/ring-closing strategy for the heterocyclic conversion of benzoxazin-4-ones to oxazolines

Abstract

A facile metal-free tandem ring-opening/ring-closing strategy was developed for the synthesis of oxazolines in good to excellent reaction yields under mild reaction conditions. This reaction essentially describes a novel tool for the heterocyclic conversion of benzoxazin-4-ones to 2,5-disubstituted oxazolines directly in one-pot.