Issue 5, 2016

Photothermal and photodynamic therapy reagents based on rGO–C6H4–COOH

Abstract

A photothermal therapy (PTT) and photodynamic therapy (PDT) reagent was synthesized based on rGO–C6H4–COOH (graphene diazotized). rGO–C6H4–COOH was first conjugated with polyethyleneimine (PEI) to enhance water solubility and then tetrakis(4-carboxyphenyl) porphyrin (TCPP) was further attached to obtain PDT ability for the system. The rGO–PEI–TCPP system exhibited excellent stability in various biological solutions and the cytotoxicity of this rGO–PEI–TCPP system was acceptable. The CBRH7919 cancer cells could be induced to effectively undergo apoptosis by rGO–PEI–TCPP under laser irradiation. The reason is mainly attributed to the excellent photothermal and photodynamic effects, i.e., the production of heat and singlet oxygen. At the same time, the CBRH7919 cancer cells could be pushed to the vulnerable G2 phase of the cell cycle, which is the most sensitive and susceptible stage to damage by radiation.

Graphical abstract: Photothermal and photodynamic therapy reagents based on rGO–C6H4–COOH

Supplementary files

Article information

Article type
Paper
Submitted
14 Nov 2015
Accepted
11 Dec 2015
First published
14 Dec 2015

RSC Adv., 2016,6, 3748-3755

Author version available

Photothermal and photodynamic therapy reagents based on rGO–C6H4–COOH

G. Wei, M. Yan, L. Ma and C. Wang, RSC Adv., 2016, 6, 3748 DOI: 10.1039/C5RA23986A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements