Issue 5, 2016

The bi-functional roles of Ca-Y zeolite in the treatment of ethanol–HCl induced gastric ulcer using a mice model

Abstract

A calcium(II) exchanged zeolite Y (Ca-Y) was prepared and evaluated in ethanol–HCl induced gastric ulcer using a mice model. Benefiting from the high procoagulant activity, good resistance to gastric fluid and anti-acid capability of Ca-Y, a significantly reduced ulcer area percentage from 35.1% ± 4.4% to 11.5% ± 1.9%, was achieved at an oral dosage of 5.0 g kg−1, along with an increased intragastric pH from 2.0 ± 0.5 to 4.5 ± 0.5.

Graphical abstract: The bi-functional roles of Ca-Y zeolite in the treatment of ethanol–HCl induced gastric ulcer using a mice model

Supplementary files

Article information

Article type
Communication
Submitted
19 Nov 2015
Accepted
16 Dec 2015
First published
18 Dec 2015

RSC Adv., 2016,6, 3458-3461

Author version available

The bi-functional roles of Ca-Y zeolite in the treatment of ethanol–HCl induced gastric ulcer using a mice model

X. Shang, H. Chen, Y. Qu and J. Fan, RSC Adv., 2016, 6, 3458 DOI: 10.1039/C5RA24467F

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