Efficient and facile synthesis of fused benzimidazole-diazepinones and dibenzimidazole-diazepines via a UDC strategy and the hydroamination of an alkyne

Abstract

Two facile approaches have been developed for the synthesis of fused benzimidazole-diazepinones and dibenzimidazole-diazepines based on an Ugi/de-protection/cyclization strategy and the hydroamination of an alkyne. This efficient cascade process afforded the target compounds in good yields via a facile one-pot operation involving the formation of a new C–N bond.