Issue 35, 2016, Issue in Progress
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RSC Advances

A new view of graphene oxide biosafety in a water environment using an eatable fish as a model†

Keyi Ma,‡a   Shupeng Zhang,‡bc   Baoqing Ye,a   Jianyong Ouyangc  and  Gen Hua Yue*ade  

* Corresponding authors

a Molecular Population Genetics and Breeding Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore
E-mail: genhua@tll.org.sg
Tel: +65 68727405

b School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, P. R. China

c Department of Materials Science and Engineering, National University of Singapore, Singapore

d Department of Biological Sciences, National University of Singapore, Singapore, Singapore

e School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

Abstract

A comprehensive evaluation on the biosafety of graphene oxide (GO) was developed by combining 16S rRNA sequencing, gene expression detection, histology and a scanning electron microscope assay on fish. GO does not affect the diversity and composition of gut microbiota, but down-regulates gene expression in fish liver, suggesting that it poses a potential risk to aquatic ecosystems.

Graphical abstract: A new view of graphene oxide biosafety in a water environment using an eatable fish as a model

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Article information

DOI
https://doi.org/10.1039/C5RA26026D
Article type
Communication
Submitted
07 Dec 2015
Accepted
15 Mar 2016
First published
18 Mar 2016

RSC Adv., 2016,6, 29619-29623

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A new view of graphene oxide biosafety in a water environment using an eatable fish as a model

K. Ma, S. Zhang, B. Ye, J. Ouyang and G. H. Yue, RSC Adv., 2016, 6, 29619 DOI: 10.1039/C5RA26026D

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