Issue 24, 2016

Multifunctional single-drug loaded nanoparticles for enhanced cancer treatment with low toxicity in vivo

Abstract

Platinum(II) complexes are used for treating over half of cancers in the clinic. However, their application is accompanied with acquired resistance and severe toxic side effects. To address these challenges, a multifunctional single drug constructed from a photo-activated oxaliplatin(IV) complex and DMC was conjugated to polymer to form multifunctional single-drug-loaded nanoparticles. When the nanoparticles are internalized by cancer cells via endocytosis, active oxaliplatin(II) can be released upon UVA irradiation to attack DNA, while DMC will be hydrolyzed subsequently from the polymer chain within the intracellular environment to block DNA repair by PP2A inhibition. The multifunctional single-drug-loaded nanoparticles exhibited enhanced anti-cancer efficacy and decreased toxicity compared to oxaliplatin(II) in vitro and in vivo. This enhanced cancer treatment strategy could have potential clinical use in the near future.

Graphical abstract: Multifunctional single-drug loaded nanoparticles for enhanced cancer treatment with low toxicity in vivo

Supplementary files

Article information

Article type
Paper
Submitted
10 Dec 2015
Accepted
11 Feb 2016
First published
15 Feb 2016

RSC Adv., 2016,6, 20366-20373

Multifunctional single-drug loaded nanoparticles for enhanced cancer treatment with low toxicity in vivo

Y. Cong, Z. Wang, S. He, D. Zhou, J. Li, Z. Xie, X. Chen, X. Jing and Y. Huang, RSC Adv., 2016, 6, 20366 DOI: 10.1039/C5RA26372G

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