Issue 29, 2016
From the journal:

RSC Advances

Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization†‡

Shiv Dhiman,a   Hitesh Kumar Saini,a   Nitesh Kumar Nandwana,a   Dalip Kumara  and  Anil Kumar*a  

* Corresponding authors

a Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India
E-mail: anilkumar@pilani.bits-pilani.ac.in

Abstract

A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.

Graphical abstract: Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

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Article information

DOI
https://doi.org/10.1039/C6RA03798D
Article type
Paper
Submitted
10 Feb 2016
Accepted
17 Feb 2016
First published
23 Feb 2016

RSC Adv., 2016,6, 23987-23994

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Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

S. Dhiman, H. K. Saini, N. K. Nandwana, D. Kumar and A. Kumar, RSC Adv., 2016, 6, 23987 DOI: 10.1039/C6RA03798D

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