Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama

Faviola Cardoso-Martínez; José M. de la Rosa; Ana R. Díaz-Marrero; José Darias; Luis D'Croz; M. Dolores Jiménez-Antón; M. Jesús Corral; Rocío García; José M. Alunda; Mercedes Cueto

doi:10.1039/C6RA04521A

Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama†

Faviola Cardoso-Martínez,^a José M. de la Rosa,^a Ana R. Díaz-Marrero,‡^a José Darias,^a Luis D'Croz,^bc M. Dolores Jiménez-Antón,^de M. Jesús Corral,^de Rocío García,^de José M. Alunda^de and Mercedes Cueto*^a

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^a Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain
E-mail: mcueto@ipna.csic.es

^b Departamento de Biología Marina y Limnología, Universidad de Panamá, Panama

^c Smithsonian Tropical Research Institute, STRI, Box 0843-03092, Balboa, Panama

^d Departamento de Sanidad Animal (Grupo UCM 910993 ICPVet), Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain

^e Instituto de Investigación Hospital 12 de Octubre, Avda de Córdoba, s/n, 28041, Madrid, Spain

Abstract

Eighteen new oxysterols have been isolated from a previously undescribed octocoral collected from the eastern Pacific of Panama. Their structures were determined based on spectroscopic evidence. The absolute configuration was established by derivatization with (R)- and (S)-MPA. Antimicrobial and antileishmanial effects were evaluated.

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Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama†

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Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama

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