Copper-loaded hypercrosslinked polymer decorated with pendant amine groups: a green and retrievable catalytic system for quick [3 + 2] Huisgen cycloaddition in water

Abstract

A novel heterogeneous copper catalyst based on a 3D-network polymer containing pendant amine groups was synthesized via post-functionalization of the polymeric backbone followed by incorporation of copper(I) ions. Catalytic activity of the newly designed catalyst was tested in a one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles by click reactions between primary halides, sodium azide and terminal acetylenes in water under aerobic conditions. It increases the reaction rate many fold when compared with common transition metal catalysts. The synergistic incorporation of the porous matrix and active sites of this new catalyst offered a unique combination for effective catalytic-substrate interactions, which made it a new class of solid-support transition metal catalysts for chemical preparation.