Self-assembly of isomannide-based monoesters of C18-fatty acids and their cellular uptake studies

Prabhu Dhasaiyan; Nimisha Parekh; T. Vijai Kumar Reddy; G. Sandhya Rani; B. L. A. Prabhavathi Devi; B. L. V. Prasad

doi:10.1039/C6RA05608C

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Self-assembly of isomannide-based monoesters of C₁₈-fatty acids and their cellular uptake studies†

Prabhu Dhasaiyan,^ab Nimisha Parekh,^c T. Vijai Kumar Reddy,^d G. Sandhya Rani,^d B. L. A. Prabhavathi Devi*^d and B. L. V. Prasad*^ab

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* Corresponding authors

^a Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune – 411008, India
E-mail: pl.bhagavatula@ncl.res.in
Fax: +91 20 25902636
Tel: +91 20 25902013

^b Academy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India

^c Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune – 411008, India

^d Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Hyderabad – 500007, India
E-mail: prabhavathi@iict.res.in
Fax: +91 40 27193370
Tel: +91 40 27191845

Abstract

The self-assembling behavior of oleic, elaidic and stearic acid-isomannide glycolipids is revealed. Amongst these, oleic and elaidic acid-based isomannide lipids self-assembled to form microspheres which were efficiently taken up by cancer cell lines enabling their usage for drug delivery applications.

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Article information

DOI: https://doi.org/10.1039/C6RA05608C
Article type: Communication
Submitted: 02 Mar 2016
Accepted: 18 Jul 2016
First published: 19 Jul 2016

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RSC Adv., 2016,6, 72074-72079

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Self-assembly of isomannide-based monoesters of C₁₈-fatty acids and their cellular uptake studies

P. Dhasaiyan, N. Parekh, T. Vijai Kumar Reddy, G. Sandhya Rani, B. L. A. Prabhavathi Devi and B. L. V. Prasad, RSC Adv., 2016, 6, 72074 DOI: 10.1039/C6RA05608C

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