Synthesis of benzoimidazoquinazolines by cobalt-catalyzed isocyanide insertion–cyclization

Abstract

An efficient and practical protocol for the synthesis of benzoimidazoquinazoline amines in moderate to good yields by the reaction of isocyanides and benzo[d]imidazol-anilines via a cobalt-catalyzed isocyanide insertion cyclization reaction into the two N–H active bonds is reported.