Issue 48, 2016
From the journal:

RSC Advances

Nickel-catalyzed α-benzylation of sulfones with esters via C–O activation†

Jing Xiao,a   Jia Yang,a   Tieqiao Chen*a  and  Li-Biao Han*ab  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemo Metrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: chentieqiao@hnu.edu.cn

b National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan
E-mail: libiao-han@aist.go.jp

Abstract

The nickel-catalyzed α-benzylation of sulfones with readily available benzylic alcohol derivatives was achieved via C–O activation. The transformation was complete in 30 minutes using a simple Ni(COD)2 as a catalyst without any additional ligands. A variety of substituted sulfones including the building block for bioactive compound eletriptan were synthesized by using the strategy.

Graphical abstract: Nickel-catalyzed α-benzylation of sulfones with esters via C–O activation

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Article information

DOI
https://doi.org/10.1039/C6RA07130A
Article type
Communication
Submitted
18 Mar 2016
Accepted
18 Apr 2016
First published
20 Apr 2016

RSC Adv., 2016,6, 42656-42659

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Nickel-catalyzed α-benzylation of sulfones with esters via C–O activation

J. Xiao, J. Yang, T. Chen and L. Han, RSC Adv., 2016, 6, 42656 DOI: 10.1039/C6RA07130A

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