Issue 59, 2016, Issue in Progress
From the journal:

RSC Advances

Concise syntheses of bridged morpholines†

Andrey V. Zaytsev,a   James E. Pickles,b   Suzannah J. Harnor,b   Alistair P. Henderson,a   Mohammed Alyasiri,b   Paul G. Waddell,c   Celine Cano,b   Roger J. Griffin‡b  and  Bernard T. Golding*ab  

* Corresponding authors

a NewChem Technologies Ltd., Holly Lodge, Whitesmocks, Durham, UK
E-mail: bernard.golding@ncl.ac.uk

b Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK

c School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne, UK

Abstract

Concise and practical syntheses of 8-oxa-3-aza-bicyclo[3.2.1]octane and 9-oxa-3-aza-bicyclo[3.3.1]nonane are described starting from furan-2,5-dicarboxylic acid and 4H-pyran-2,6-dicarboxylic acid, respectively, and using a solvent-free step for a key cyclisation.

Graphical abstract: Concise syntheses of bridged morpholines

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Article information

DOI
https://doi.org/10.1039/C6RA08737J
Article type
Communication
Submitted
05 Apr 2016
Accepted
25 May 2016
First published
27 May 2016

RSC Adv., 2016,6, 53955-53957

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Concise syntheses of bridged morpholines

A. V. Zaytsev, J. E. Pickles, S. J. Harnor, A. P. Henderson, M. Alyasiri, P. G. Waddell, C. Cano, R. J. Griffin and B. T. Golding, RSC Adv., 2016, 6, 53955 DOI: 10.1039/C6RA08737J

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