A metal-free process for the C-3 alkylation of imidazopyridines has been developed. Various alkylation products including alkyl ester-, cyano-, ketone- and amide-substituted imidazopyridines were prepared in good yields. With this method, a highly efficient and concise formal synthesis of alpidem (A) and zolpidem (B) has been completed.
S. Wang, X. Huang, Z. Ge, X. Wang and R. Li, RSC Adv., 2016, 6, 63532 DOI: 10.1039/C6RA09046J
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