Issue 61, 2016, Issue in Progress

Primaquine-based ionic liquids as a novel class of antimalarial hits

Abstract

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

Graphical abstract: Primaquine-based ionic liquids as a novel class of antimalarial hits

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2016
Accepted
06 Jun 2016
First published
07 Jun 2016

RSC Adv., 2016,6, 56134-56138

Primaquine-based ionic liquids as a novel class of antimalarial hits

R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. Prudêncio, S. Parapini, S. D'Alessandro, C. Teixeira, A. Gomes, C. Prudêncio and P. Gomes, RSC Adv., 2016, 6, 56134 DOI: 10.1039/C6RA10759A

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