Issue 64, 2016, Issue in Progress

TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3

Abstract

A novel and efficient TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3 via a radical mechanism process is described. This methodology provides an easy access to a variety of useful 5-substituted isoxazoles from simple and readily available propargylic ketones and TMSN3 in good to excellent yields. A plausible reaction mechanism for this process is proposed.

Graphical abstract: TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3

Supplementary files

Article information

Article type
Paper
Submitted
29 Apr 2016
Accepted
13 Jun 2016
First published
13 Jun 2016

RSC Adv., 2016,6, 58988-58993

TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3

Y. He, Y. Xie, Y. Wang, X. Bin, D. Hu, H. Wang and Y. Pan, RSC Adv., 2016, 6, 58988 DOI: 10.1039/C6RA11099A

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