Synthesis of 3-phosphinoylquinolines via a phosphinoylation–cyclization–aromatization process mediated by tert-butyl hydroperoxide

Abstract

The first metal-free phosphinoylation–cyclization–aromatization method has been developed. The present methodology produces a series of substituted 3-phosphinoylquinolines in moderate to good yields from N-propargylanilines and H-phosphine oxides mediated by tert-butyl hydroperoxide.