Near-infrared fluorescent probes with higher quantum yields and neutral pKa values for the evaluation of intracellular pH

Xinbo Song; Mingyu Hu; Chao Wang; Yi Xiao

doi:10.1039/C6RA11637J

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Near-infrared fluorescent probes with higher quantum yields and neutral pK_a values for the evaluation of intracellular pH†

Xinbo Song,^a Mingyu Hu,^a Chao Wang^a and Yi Xiao*^a

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, West Campus, 2 Linggong Road, Dalian 116024, China
E-mail: xiaoyi@dlut.edu.cn

Abstract

We have developed two near-infrared fluorescent probes for pH, named pH-A and pH-B. The fluorescence quantum yields of pH-A and pH-B are 0.19 and 0.095 in methanol. And there is the neutral pK_a value of pH-A (pK_a = 7.2). What is the most important is that these probes can stain the cells, which can reflect the changes of pH in cells.

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Article information

DOI: https://doi.org/10.1039/C6RA11637J
Article type: Communication
Submitted: 05 May 2016
Accepted: 08 Jul 2016
First published: 08 Jul 2016

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RSC Adv., 2016,6, 69641-69646

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Near-infrared fluorescent probes with higher quantum yields and neutral pK_a values for the evaluation of intracellular pH

X. Song, M. Hu, C. Wang and Y. Xiao, RSC Adv., 2016, 6, 69641 DOI: 10.1039/C6RA11637J

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