Issue 65, 2016
From the journal:

RSC Advances

pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue†

A. M. Demin,‡a   A. G. Pershina,‡*bc   K. V. Nevskaya,b   L. V. Efimova,b   N. N. Shchegoleva,d   M. A. Uimin,d   D. K. Kuznetsov,e   V. Ya. Shur,e   V. P. Krasnova  and  L. M. Ogorodovab  

* Corresponding authors

a Postovsky Institute of Organic Synthesis of RAS (Ural Branch), Yekaterinburg, Russia

b Siberian State Medical University, Tomsk, Russia
E-mail: allysyz@mail.ru
Fax: +7 382 2533309
Tel: +7 382 2901101 ext. 1634

c Russian National Research Tomsk Polytechnic University, Tomsk, Russia

d Mikheev Institute of Metal Physics of RAS (Ural Branch), Yekaterinburg, Russia

e Ural Centre for Shared Use “Modern Nanotechnology”, Institute of Natural Sciences, Ural Federal University, Yekaterinburg, Russia

Abstract

Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

Graphical abstract: pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

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Article information

DOI
https://doi.org/10.1039/C6RA13178F
Article type
Communication
Submitted
23 May 2016
Accepted
06 Jun 2016
First published
13 Jun 2016

RSC Adv., 2016,6, 60196-60199

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pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

A. M. Demin, A. G. Pershina, K. V. Nevskaya, L. V. Efimova, N. N. Shchegoleva, M. A. Uimin, D. K. Kuznetsov, V. Ya. Shur, V. P. Krasnov and L. M. Ogorodova, RSC Adv., 2016, 6, 60196 DOI: 10.1039/C6RA13178F

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