Copper-catalyzed tandem reaction in ionic liquid: an efficient reusable catalyst and solvent media for the synthesis of fused poly hetero cyclic compounds

Abstract

Herein we report a copper catalyzed tandem reaction for the synthesis of therapeutically important pyrrolo-/pyrido[2,1-b] benzo[d][1,3]oxazin-1-ones from 2-aminobezyl alcohols using alkynoic acids under ligand and base free conditions in the presence of a green solvent medium [bmim]OTf. The catalyst and solvent were successfully recycled and reused.