Issue 84, 2016, Issue in Progress
From the journal:

RSC Advances

GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release†

Hongliang Cao,*a   Huajie Song,a   Debiao Xie,a   Chao Chen,b   Xin Chen,*ac   Ping Wangb  and  Wenxin Wangd  

* Corresponding authors

a Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
E-mail: caohl@ecust.edu.cn, xinchen73@ecust.edu.cn

b School of Biotechnology and State Key Laboratory of Bioreactor Engineering, Biomedical Nanotechnology Center, East China University of Science and Technology, Shanghai, P. R. China

c State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, 865 Changning Road, Shanghai 200050, P. R. China

d The Charles Institute of Dermatology, School of Medicine and Medical Science, University College of Dublin, Dublin, Ireland

Abstract

We report a glutathione (GSH) responsive drug carrier that is based on the Michael addition reaction between an olefinic bond and GSH. Amphiphilic copolymers with multi-linear-cyclized and branched structures that contain vinyl groups were successfully synthesized by deactivation enhanced atom transfer radical polymerization (DE-ATRP). The polymers self-assembled into GSH responsive micelles with sizes of 68 to 97 nm and spherical morphology. The core cross-linked micelles were confirmed to greatly decrease doxorubicin (DOX) leakage due to the concentration gradient. Drug release experiments indicated that the drug carrier containing no disulfide has the same responsive ability as a conventional GSH reduction responsive carrier with a similar polymer structure. MTT assays showed that the blank micelles are totally non-cytotoxic, while the DOX-loaded micelles exhibit GSH-dependent behaviour.

Graphical abstract: GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

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Article information

DOI
https://doi.org/10.1039/C6RA15302J
Article type
Paper
Submitted
13 Jun 2016
Accepted
07 Aug 2016
First published
10 Aug 2016

RSC Adv., 2016,6, 80896-80904

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GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

H. Cao, H. Song, D. Xie, C. Chen, X. Chen, P. Wang and W. Wang, RSC Adv., 2016, 6, 80896 DOI: 10.1039/C6RA15302J

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