A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging

Zhao Ma; Yuxing Lin; Hui Chen; Lupei Du; Minyong Li

doi:10.1039/C6RA16996A

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A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging†

Zhao Ma,^a Yuxing Lin,^a Hui Chen,^a Lupei Du^a and Minyong Li

*^a

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* Corresponding authors

^a Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
E-mail: mli@sdu.edu.cn
Fax: +86-531-8838-2076
Tel: +86-531-8838-2076

Abstract

A novel PET-based fluorescent probe (LN6) targeting to lysosome was found from the synthesized NBD derivatives. This probe was equipped with the novel lysosome-targeted N-phenylpiperazine group, and could be employed to image lysosome and detect its pH change without any washing steps.

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Article information

DOI: https://doi.org/10.1039/C6RA16996A
Article type: Paper
Submitted: 02 Jul 2016
Accepted: 22 Oct 2016
First published: 24 Oct 2016

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RSC Adv., 2016,6, 102773-102777

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A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging

Z. Ma, Y. Lin, H. Chen, L. Du and M. Li, RSC Adv., 2016, 6, 102773 DOI: 10.1039/C6RA16996A

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A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging†

Abstract

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A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging

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