Issue 94, 2016

Tetrocarcins N and O, glycosidic spirotetronates from a marine-derived Micromonospora sp. identified by PCR-based screening

Abstract

Two new glycosidic spirotetronate antibiotics, tetrocarcins N (1) and O (2), were isolated and identified from the marine-derived Micromonospora sp. 5-297 using a PCR-based genetic screening method targeting the dTDP-glucose-4,6-dehydratase gene. Their structures were determined by extensive IR, NMR, and MS spectroscopic analyses. Tetrocarcin O (2) is a derivative of 1 that lacks the terminal L-amicetose moiety at C-9. Compound 1 and 2 exhibited antibacterial activity against Bacillus subtilis with MIC values of 2 and 64 μg mL−1, respectivly. It seems that the sugar moieties at C-9 and the formyl group at C-32 play important roles in the antibacterial activity of the tetrocarcins.

Graphical abstract: Tetrocarcins N and O, glycosidic spirotetronates from a marine-derived Micromonospora sp. identified by PCR-based screening

Supplementary files

Article information

Article type
Paper
Submitted
02 Jul 2016
Accepted
18 Sep 2016
First published
19 Sep 2016

RSC Adv., 2016,6, 91773-91778

Tetrocarcins N and O, glycosidic spirotetronates from a marine-derived Micromonospora sp. identified by PCR-based screening

Y. Tan, Y. Hu, Q. Wang, H. Zhou, Y. Wang and M. Gan, RSC Adv., 2016, 6, 91773 DOI: 10.1039/C6RA17026A

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