Issue 91, 2016, Issue in Progress

Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins

Abstract

Seven new ansatrienin-type ansamycins, namely, ansatrienols B–H (1–7), along with four known ones (8–11), were isolated from the strain Streptomyces sp. XZQH13OEΔastC constructed by deleting the astC gene responsible for the assembly of the N-cyclohexanoyl D-alanyl side chain. Their structures were determined by analysis of the 1D and 2D NMR spectroscopic data and high-resolution ESIMS. This study revealed the diverse post-PKS modifications during the biosynthesis of ansatrienins.

Graphical abstract: Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins

Supplementary files

Article information

Article type
Paper
Submitted
27 Jul 2016
Accepted
27 Aug 2016
First published
31 Aug 2016

RSC Adv., 2016,6, 88571-88579

Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins

X. Li, J. Zhu, G. Shi, M. Sun, Z. Guo, H. Wang, C. Lu and Y. Shen, RSC Adv., 2016, 6, 88571 DOI: 10.1039/C6RA19036G

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