Issue 90, 2016, Issue in Progress
From the journal:

RSC Advances

A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes†

Krishna Gavvala,‡a   Nicolas P. F. Barthes,‡b   Dominique Bonhomme,b   Anne Sophie Dabert-Gay,c   Delphine Debayle,c   Benoît Y. Michel,b   Alain Burger*b  and  Yves Mély*a  

* Corresponding authors

a Laboratoire de Biophotonique et Pharmacologie, UMR 7213, Faculté de Pharmacie, Université de Strasbourg, CNRS, 74 Route du Rhin, 67401 Illkirch, France
E-mail: yves.mely@unistra.fr

b Institut de Chimie de Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS, Parc Valrose, 06108 Nice Cedex 2, France
E-mail: Alain.BURGER@unice.fr

c Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097, Université de Nice Sophia Antipolis, 660 Route des Lucioles, 06560 Valbonne, France

Abstract

Herein, a 2-furyl-3-hydroxychromone-based deoxyuridine analogue was synthesized and incorporated into DNA. Its ESIPT mechanism, investigated by steady-state and time-resolved spectroscopy, was found to be highly sensitive to hydration through its ratiometric response. As a result, this analogue demonstrated a unique on–off dual emissive behavior which allows monitoring DNA hybridization as well as discriminating matched from mismatched duplexes, and B from A conformations.

Graphical abstract: A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes

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Article information

DOI
https://doi.org/10.1039/C6RA19061H
Article type
Communication
Submitted
27 Jul 2016
Accepted
07 Sep 2016
First published
07 Sep 2016

RSC Adv., 2016,6, 87142-87146

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A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes

K. Gavvala, N. P. F. Barthes, D. Bonhomme, A. S. Dabert-Gay, D. Debayle, B. Y. Michel, A. Burger and Y. Mély, RSC Adv., 2016, 6, 87142 DOI: 10.1039/C6RA19061H

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