Issue 96, 2016, Issue in Progress
From the journal:

RSC Advances

Azobenzene-modified antisense oligonucleotides for site-specific cleavage of RNA with photocontrollable property†

Xingyu Wangab  and  Xingguo Liang*a  

* Corresponding authors

a School of Food Science and Engineering, Ocean University of China, Yushan Road No.5, Qingdao, Shandong, China
E-mail: liangxg@ouc.edu.cn

b College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China

Abstract

We presented a RNase H-based strategy for site-specific RNA cleavage using azobenzene-modified antisense oligonucleotides (ASO). The results showed that RNase H can bind to the ASO–RNA heteroduplex, and cut the RNA strand at predetermined sites. Moreover, cleavage rate can be regulated by photoirradiation, with a 5-fold photomodulation efficiency at most.

Graphical abstract: Azobenzene-modified antisense oligonucleotides for site-specific cleavage of RNA with photocontrollable property

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Article information

DOI
https://doi.org/10.1039/C6RA20954H
Article type
Communication
Submitted
20 Aug 2016
Accepted
19 Sep 2016
First published
19 Sep 2016

RSC Adv., 2016,6, 93398-93402

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Azobenzene-modified antisense oligonucleotides for site-specific cleavage of RNA with photocontrollable property

X. Wang and X. Liang, RSC Adv., 2016, 6, 93398 DOI: 10.1039/C6RA20954H

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