Issue 96, 2016, Issue in Progress
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RSC Advances

Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides†

Alexander V. Aksenov,*a   Nicolai A. Aksenov,ab   Zarema V. Dzhandigova,a   Dmitrii A. Aksenov,a   Leonid G. Voskressensky,b   Valentine G. Nenajdenkoc  and  Michael Rubin ORCID logo *ad  

* Corresponding authors

a Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation
E-mail: alexaks05@rambler.ru

b Department of Organic Chemistry, People's Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, Russian Federation

c Department of Chemistry, Lomonosov Moscow State University, Moscow 119899, Russia
E-mail: nenajdenko@org.chem.msu.ru

d Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA
E-mail: mrubin@ku.edu
Fax: +1-785-864-5396
Tel: +1-785-864-5071

Abstract

A highly efficient one-pot method for the reductive coupling of indoles to nitrostyrenes in polyphosphoric acid doped with PCl3 was developed. This method allows direct and expeditious access to primary (indol-3-yl)acetamides, interesting as anti-cancer drug candidates.

Graphical abstract: Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides

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Article information

DOI
https://doi.org/10.1039/C6RA21399E
Article type
Paper
Submitted
25 Aug 2016
Accepted
26 Sep 2016
First published
27 Sep 2016

RSC Adv., 2016,6, 93881-93886

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Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides

A. V. Aksenov, N. A. Aksenov, Z. V. Dzhandigova, D. A. Aksenov, L. G. Voskressensky, V. G. Nenajdenko and M. Rubin, RSC Adv., 2016, 6, 93881 DOI: 10.1039/C6RA21399E

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