Issue 114, 2016, Issue in Progress
From the journal:

RSC Advances

Interactive luminescent gold nanocluster embedded dsDNA and cisplatin as model nanoparticles for cancer theranostics†‡

Bandhan Chatterjee,a   Amaresh Kumar Sahoo,a   Siddhartha Sankar Ghosh*ab  and  Arun Chattopadhyay*ac  

* Corresponding authors

a Centre for Nanotechnology, Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati – 781039, Assam, India
E-mail: sghosh@iitg.ernet.in

b Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

c Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India
E-mail: arun@iitg.ernet.in

Abstract

Plasmid DNA embedded with luminescent gold nanoclusters were reacted with cisplatin to form composite nanoparticles (composite NPs) for theranostic applications. The composite NPs delivered the cisplatin to cervical cancer HeLa cells in vitro, inducing apoptosis mediated cell death. The luminescent gold nanoclusters were simultaneously used for cellular imaging.

Graphical abstract: Interactive luminescent gold nanocluster embedded dsDNA and cisplatin as model nanoparticles for cancer theranostics

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Article information

DOI
https://doi.org/10.1039/C6RA24325H
Article type
Communication
Submitted
30 Sep 2016
Accepted
22 Nov 2016
First published
22 Nov 2016

RSC Adv., 2016,6, 113053-113057

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Interactive luminescent gold nanocluster embedded dsDNA and cisplatin as model nanoparticles for cancer theranostics

B. Chatterjee, A. K. Sahoo, S. S. Ghosh and A. Chattopadhyay, RSC Adv., 2016, 6, 113053 DOI: 10.1039/C6RA24325H

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