Palladium-catalyzed cross-dehydrogenative coupling of maleimides with simple arenes: a fast track to highly substituted maleimides†
Abstract
Pd-catalyzed cross-dehydrogenative coupling of N-substituted maleimides with simple arenes is explored. The protocol provides a versatile and atom-economic method for construction of a range of highly functionalized maleimides. The study unveils that a combination of TFA/PivOH is critical for diarylation.