Xiaoyu Yang and F. Dean Toste
Chem. Sci., 2016,7, 2653-2656
DOI:
10.1039/C5SC04202J,
Edge Article
Open Access Learn more..We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis.
