Issue 4, 2016

Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA

Abstract

Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of complexed lanthanide ions.

Graphical abstract: Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA

Supplementary files

Article information

Article type
Edge Article
Submitted
23 Nov 2015
Accepted
10 Jan 2016
First published
11 Jan 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 2674-2678

Author version available

Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNA

C. Penas, J. L. Mascareñas and M. E. Vázquez, Chem. Sci., 2016, 7, 2674 DOI: 10.1039/C5SC04501K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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