Issue 7, 2016

Ruthenium(ii) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

Abstract

Multifunctionalized porous silicon nanoparticles (pSiNPs), containing the novel Ru(II) complex-photosensitizer, the polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed and showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) and imaging of cancer. Exposure to NIR light leads to two-photon excitation of the Ru(II)-complex which allows efficient simultaneous cancer-imaging and targeted PDT therapy with the functionalized biodegradable pSiNP nanocarriers.

Graphical abstract: Ruthenium(ii) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
23 Dec 2015
Accepted
14 Jan 2016
First published
14 Jan 2016

J. Mater. Chem. B, 2016,4, 1337-1342

Ruthenium(II) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

N. Ž. Knežević, V. Stojanovic, A. Chaix, E. Bouffard, K. E. Cheikh, A. Morère, M. Maynadier, G. Lemercier, M. Garcia, M. Gary-Bobo, J. Durand and F. Cunin, J. Mater. Chem. B, 2016, 4, 1337 DOI: 10.1039/C5TB02726H

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