Layered MoS2 nanoflowers for microwave thermal therapy

Abstract

Microwave (MW) hyperthermia has received great attention as an emerging green tumor thermotherapy. In this work, layered MoS₂ nanoflowers were prepared through a simple bottom-up hydrothermal process. By coating MoS₂ nanoflowers with bovine serum albumin (BSA-MoS₂), BSA-MoS₂ exhibits low biotoxicity and excellent microwave susceptive properties in vitro. Meanwhile, the heating effect improvement by the layered structure was confirmed via a computer-simulated experiment. Finally, layered BSA-MoS₂ nanoflowers are designed as MW hyperthermia susceptible agents for in vivo cancer therapy with 100% tumor elimination via MW irradiation at 1.8 W, 450 MHz.