Issue 22, 2016
From the journal:

Journal of Materials Chemistry B

A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance

Juan Liu,†a   Xiaowei Ma,†a   Chunni Lei,a   Xiangdong Xue,a   Tuo Wei,a   Jing Zhao,b   Shuyi Lia  and  Xing-Jie Liang*a  

* Corresponding authors

a CAS Center for Excellence in Nanoscience, Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and Laboratory of Controllable Nanopharmaceuticals, National Center for Nanoscience and Technology, Beijing 100190, China
E-mail: liangxj@nanoctr.cn

b Department of Histology and Embryology, Hebei Medical University, Shijiazhuang 050017, China

Abstract

We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The resulting nanostructure was able to specifically target cancer cells and release the loaded drug at pH 5.0. More importantly, the drug-loaded DNA nanostructure effectively circumvented doxorubicin resistance of human lung adenocarcinoma epithelial cancer cells.

Graphical abstract: A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance

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Article information

DOI
https://doi.org/10.1039/C6TB00761A
Article type
Communication
Submitted
25 Mar 2016
Accepted
05 May 2016
First published
06 May 2016

J. Mater. Chem. B, 2016,4, 3854-3858

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A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance

J. Liu, X. Ma, C. Lei, X. Xue, T. Wei, J. Zhao, S. Li and X. Liang, J. Mater. Chem. B, 2016, 4, 3854 DOI: 10.1039/C6TB00761A

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