Pressure controlled drug release in a Zr-cluster-based MOF

Ke Jiang; Ling Zhang; Quan Hu; Dian Zhao; Tifeng Xia; Wenxin Lin; Yanyu Yang; Yuanjing Cui; Yu Yang; Guodong Qian

doi:10.1039/C6TB01756H

Pressure controlled drug release in a Zr-cluster-based MOF†

Ke Jiang,^a Ling Zhang,^a Quan Hu,^b Dian Zhao,^a Tifeng Xia,^a Wenxin Lin,^a Yanyu Yang,^a Yuanjing Cui,*^a Yu Yang^a and Guodong Qian*^a

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* Corresponding authors

^a State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, School of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: cuiyj@zju.edu.cn, gdqian@zju.edu.cn

^b Department of Pharmacology, School of Medicine, Hangzhou Normal University, Hangzhou 310036, China

Abstract

A robust zirconium-cluster-based metal–organic framework (MOF) ZJU-800 with an excellent drug loading capacity (about 58.80 wt%) has been synthesized. The system shows an adjustable release time of the drug diclofenac sodium from 2 days to 8 days by controlling the degree of compaction between MOF and drug using pressure.

Journal of Materials Chemistry B

Pressure controlled drug release in a Zr-cluster-based MOF†

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Pressure controlled drug release in a Zr-cluster-based MOF

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