Issue 35, 2016

Nanodiamond–PMO for two-photon PDT and drug delivery

Abstract

In this article, we highlight the properties of nanodiamonds (ND), which were encapsulated in periodic mesoporous organosilica nanoparticles (PMO) and were able to generate reactive oxygen species for photodynamic applications upon two-photon excitation (TPE). The ND@PMO nanoparticles were characterized by various techniques and were then loaded with the anti-cancer drug doxorubicin. The release of the drug was pH sensitive and a synergistic cancer cell killing effect was observed when cancer cells were incubated with doxorubicin-loaded ND@PMO and irradiated with two-photon excitation at 800 nm.

Graphical abstract: Nanodiamond–PMO for two-photon PDT and drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
29 Jul 2016
Accepted
05 Aug 2016
First published
05 Aug 2016

J. Mater. Chem. B, 2016,4, 5803-5808

Nanodiamond–PMO for two-photon PDT and drug delivery

C. M. Jimenez, N. Z. Knezevic, Y. G. Rubio, S. Szunerits, R. Boukherroub, F. Teodorescu, J. G. Croissant, O. Hocine, M. Seric, L. Raehm, V. Stojanovic, D. Aggad, M. Maynadier, M. Garcia, M. Gary-Bobo and J. Durand, J. Mater. Chem. B, 2016, 4, 5803 DOI: 10.1039/C6TB01915C

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