Developing Mn-doped lead sulfide quantum dots for MRI labels

Lyudmila Turyanska; Fabrizio Moro; Amalia Patanè; James Barr; Walter Köckenberger; Alexander Taylor; Henryk M. Faas; Maxine Fowler; Peter Wigmore; Rebecca C. Trueman; Huw E. L. Williams; Neil R. Thomas

doi:10.1039/C6TB02574A

Developing Mn-doped lead sulfide quantum dots for MRI labels†

Lyudmila Turyanska,*^ab Fabrizio Moro,^a Amalia Patanè,^a James Barr,^a Walter Köckenberger,^a Alexander Taylor,^c Henryk M. Faas,^c Maxine Fowler,^c Peter Wigmore,^c Rebecca C. Trueman,^c Huw E. L. Williams^d and Neil R. Thomas^d

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* Corresponding authors

^a School of Physics and Astronomy, The University of Nottingham, UK
E-mail: Lyudmila.Turyanska@nottingham.ac.uk

^b School of Chemistry, University of Lincoln, UK

^c Faculty of Medicine and Health Sciences, The University of Nottingham, UK

^d Centre for Biomolecular Sciences, School of Chemistry, The University of Nottingham, UK

Abstract

Magnetic interactions of Mn²⁺ ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxation times. Magnetic resonance imaging of neuronal cell pellets exposed to (PbMn)S at non-toxic concentrations demonstrates their prospects as MRI-labels.

Journal of Materials Chemistry B

Developing Mn-doped lead sulfide quantum dots for MRI labels†

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