Issue 17, 2017

Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

Abstract

Enzyme-free, signal-amplified nucleic acid circuits utilize programmed assembly reactions between nucleic acid substrates to transduce a chemical input into an amplified detection signal. These circuits have shown great potential for developing biosensors for high-sensitivity and high-selectivity detection of varying targets including nucleic acids, small molecules and proteins in vitro and for high-contrast in situ visualization and imaging of these targets in tissues and living cells. We review the background of the enzyme-free, signal-amplified nucleic acid circuits, including their mechanism, significance, types and development. We also review current applications of these circuits for biosensors and bioimaging.

Graphical abstract: Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

Article information

Article type
Critical Review
Submitted
10 Jun 2017
Accepted
03 Jul 2017
First published
06 Jul 2017

Analyst, 2017,142, 3048-3061

Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

J. Chen, L. Tang, X. Chu and J. Jiang, Analyst, 2017, 142, 3048 DOI: 10.1039/C7AN00967D

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