Issue 1, 2017
From the journal:

Chemical Communications

Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation†

Gengyang Yuan,ab   Feng Wang,c   Nickeisha A. Stephenson,‡a   Lu Wang,a   Benjamin H. Rotstein,§a   Neil Vasdev,a   Pingping Tangc  and  Steven H. Liang*a  

* Corresponding authors

a Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA, USA
E-mail: liang.steven@mgh.harvard.edu
Tel: +1-617-726-6107

b Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Ave., Boston, MA, USA

c State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China

Abstract

A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.

Graphical abstract: Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

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Article information

DOI
https://doi.org/10.1039/C6CC07913J
Article type
Communication
Submitted
29 Sep 2016
Accepted
18 Nov 2016
First published
05 Dec 2016

Chem. Commun., 2017,53, 126-129

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Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

G. Yuan, F. Wang, N. A. Stephenson, L. Wang, B. H. Rotstein, N. Vasdev, P. Tang and S. H. Liang, Chem. Commun., 2017, 53, 126 DOI: 10.1039/C6CC07913J

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