Issue 1, 2017

Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

Abstract

The HIV nucleocapsid NCp7–SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for “non-covalent” molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent “fixation” by Au–Cys bond formation providing a chemotype for a new distinct class of nucleocapsid–nucleic acid antagonist.

Graphical abstract: Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

Supplementary files

Article information

Article type
Communication
Submitted
02 Oct 2016
Accepted
09 Nov 2016
First published
09 Nov 2016

Chem. Commun., 2017,53, 91-94

Au(III) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

S. R. Spell, J. B. Mangrum, E. J. Peterson, D. Fabris, R. Ptak and N. P. Farrell, Chem. Commun., 2017, 53, 91 DOI: 10.1039/C6CC07970A

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