Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells

Chenfu Liu; Chao Yang; Lihua Lu; Wanhe Wang; Weihong Tan; Chung-Hang Leung; Dik-Lung Ma

doi:10.1039/C6CC08109F

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells†

Chenfu Liu,‡^a Chao Yang,‡^b Lihua Lu,‡^ac Wanhe Wang,‡^a Weihong Tan,*^de Chung-Hang Leung*^b and Dik-Lung Ma

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

^b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
E-mail: duncanleung@umac.mo

^c College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

^d Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, USA
E-mail: tan@chem.ufl.edu

^e Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha, China

Abstract

Two luminescent iridium(III) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(III) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.

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DOI: https://doi.org/10.1039/C6CC08109F
Article type: Communication
Submitted: 07 Oct 2016
Accepted: 16 Jan 2017
First published: 16 Jan 2017

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Chem. Commun., 2017,53, 2822-2825

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Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells

C. Liu, C. Yang, L. Lu, W. Wang, W. Tan, C. Leung and D. Ma, Chem. Commun., 2017, 53, 2822 DOI: 10.1039/C6CC08109F

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Chemical Communications

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells†

Abstract

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Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells

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