Issue 10, 2017

Construction and characterisation of a heparan sulphate heptasaccharide microarray

Abstract

A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.

Graphical abstract: Construction and characterisation of a heparan sulphate heptasaccharide microarray

Supplementary files

Article information

Article type
Communication
Submitted
11 Oct 2016
Accepted
03 Jan 2017
First published
11 Jan 2017

Chem. Commun., 2017,53, 1743-1746

Construction and characterisation of a heparan sulphate heptasaccharide microarray

J. Yang, P. Hsieh, X. Liu, W. Zhou, X. Zhang, J. Zhao, Y. Xu, F. Zhang, R. J. Linhardt and J. Liu, Chem. Commun., 2017, 53, 1743 DOI: 10.1039/C6CC08204A

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