Issue 2, 2017
From the journal:

Chemical Communications

Single molecule based SNP detection using designed DNA carriers and solid-state nanopores†

Jinglin Kong, ORCID logo a   Jinbo Zhua  and  Ulrich F. Keyser ORCID logo *a  

* Corresponding authors

a Cavendish Laboratory, University of Cambridge, Cambridge, UK
E-mail: ufk20@cam.ac.uk

Abstract

Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.

Graphical abstract: Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

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Article information

DOI
https://doi.org/10.1039/C6CC08621G
Article type
Communication
Submitted
26 Oct 2016
Accepted
29 Nov 2016
First published
29 Nov 2016

Chem. Commun., 2017,53, 436-439

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Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

J. Kong, J. Zhu and U. F. Keyser, Chem. Commun., 2017, 53, 436 DOI: 10.1039/C6CC08621G

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