A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications

Xuan Fu; Wenjing Shang; Shuaishuai Wang; Yunpeng Liu; Jingyao Qu; Xi Chen; Peng George Wang; Junqiang Fang

doi:10.1039/C6CC09431G

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A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications†

Xuan Fu,^a Wenjing Shang,^a Shuaishuai Wang,^b Yunpeng Liu,^b Jingyao Qu,^a Xi Chen,

^c Peng George Wang*^ab and Junqiang Fang

*^a

Author affiliations

* Corresponding authors

^a National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Glycochemistry and Glycobiology, Shandong University, Jinan, Shandong 250100, People's Republic of China
E-mail: fangjunqiang@sdu.edu.cn

^b Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, USA
E-mail: pwang11@gsu.edu

^c Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA

Abstract

Here, we developed a general strategy for synthesizing homogeneous HA conjugates, and generated homogeneous HA–pNP, HA–biotin, and HA–oroxylin conjugates to investigate the relationships between HA chain length and its diverse biological functions.

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Article information

DOI: https://doi.org/10.1039/C6CC09431G
Article type: Communication
Submitted: 26 Nov 2016
Accepted: 28 Feb 2017
First published: 02 Mar 2017

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Chem. Commun., 2017,53, 3555-3558

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A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications

X. Fu, W. Shang, S. Wang, Y. Liu, J. Qu, X. Chen, P. G. Wang and J. Fang, Chem. Commun., 2017, 53, 3555 DOI: 10.1039/C6CC09431G

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Chemical Communications

A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications†

Abstract

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A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications

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