Issue 23, 2017
From the journal:

Chemical Communications

Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy†‡

Xiaohe Tian, ORCID logo §*ab   Yingzhong Zhu,§b   Mingzhu Zhang,ab   Lei Luo,c   Jieying Wu,b   Hongping Zhou, ORCID logo b   Lijuan Guan,de   Giuseppe Battagliade  and  Yupeng Tian ORCID logo *bf  

* Corresponding authors

a School of Life Science, Anhui University, Hefei 230039, P. R. China
E-mail: xiaohe.t@ahu.edu.cn

b Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China
E-mail: yptian@ahu.edu.cn

c College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China

d Department of Chemistry, University College London, London, UK

e Department of Chemical Engineering, University College London, London, UK

f State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China

Abstract

We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(III) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.

Graphical abstract: Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C6CC09470H
Article type
Communication
Submitted
28 Nov 2016
Accepted
15 Feb 2017
First published
15 Feb 2017

Chem. Commun., 2017,53, 3303-3306

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Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

X. Tian, Y. Zhu, M. Zhang, L. Luo, J. Wu, H. Zhou, L. Guan, G. Battaglia and Y. Tian, Chem. Commun., 2017, 53, 3303 DOI: 10.1039/C6CC09470H

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