Issue 10, 2017
From the journal:

Chemical Communications

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination†

Bo Song, ORCID logo ab   Chang-Bin Yu, ORCID logo a   Yue Ji, ORCID logo a   Mu-Wang Chen ORCID logo a  and  Yong-Gui Zhou ORCID logo *ac  

* Corresponding authors

a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
E-mail: ygzhou@dicp.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

c Collaborative Innovation Centre of Chemical Science and Engineering, Tianjin 300071, P. R. China

Abstract

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Brønsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enantioselectivity.

Graphical abstract: Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

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Article information

DOI
https://doi.org/10.1039/C6CC09493G
Article type
Communication
Submitted
29 Nov 2016
Accepted
05 Jan 2017
First published
05 Jan 2017

Chem. Commun., 2017,53, 1704-1707

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Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

B. Song, C. Yu, Y. Ji, M. Chen and Y. Zhou, Chem. Commun., 2017, 53, 1704 DOI: 10.1039/C6CC09493G

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