The first nucleophilic C–H perfluoroalkylation of aromatic compounds via (arene)tricarbonylchromium complexes

Abstract

The first nucleophilic perfluoroalkylation of arenes is based on the arene π-system activation via (η⁶-arene)tricarbonylchromium complexes. Perfluoroalkyl anions generated from Me₃SiR_F and a fluoride ion source [Me₄N]F exclusively attack the arene ligand under mild conditions. The formed negatively charged analogs of Meisenheimer adducts readily undergo a one-pot oxidation to perfluoroalkyl arenes.