We developed a one-pot peptide ligation method using two orthogonal thioester precursors and a protecting group for the ligation reaction between Asp and Cys. Combination of the two precursors facilitated the one-pot operation and yielded the entire polypeptide. The usefulness of this method was successfully demonstrated by the total synthesis of histone H4.
Y. Asahina, T. Kawakami and H. Hojo, Chem. Commun., 2017, 53, 2114 DOI: 10.1039/C6CC10243C
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