Issue 23, 2017
From the journal:

Chemical Communications

N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles†

Battu Harish,ab   Manyam Subbireddya  and  Surisetti Suresh ORCID logo *ab  

* Corresponding authors

a Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India
E-mail: surisetti@iict.res.in, suresh.surisetti@yahoo.in

b Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India

Abstract

A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.

Graphical abstract: N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles

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Article information

DOI
https://doi.org/10.1039/C6CC10292A
Article type
Communication
Submitted
29 Dec 2016
Accepted
31 Jan 2017
First published
31 Jan 2017

Chem. Commun., 2017,53, 3338-3341

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N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles

B. Harish, M. Subbireddy and S. Suresh, Chem. Commun., 2017, 53, 3338 DOI: 10.1039/C6CC10292A

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